Publikationen

Fetal surgery for spina bifida in Zurich: results from 150 cases

Ueli Moehrlen 1, 2, 3, 4, Nicole Ochsenbein 5, 6, 7, Ladina Vonzun 5, 6, Luca Mazzone 8, 5, 9, 10, Maya Horst 8, 9, 10, Sonja Schauer 8, 9, 10, David Alexander Wille 11, 9, 10, Cornelia Hagmann 12, 10, Raimund Kottke 13, 10, Patrice Grehten 13, 10, Barbara Casanova 8, 5, 10, Nele Strübing 5, 6, Theres Moehrlen 8, 5, 10, Sasha Tharakan 8, 5, 10, Beth Padden 14, 9, 10, Dirk Bassler 15, 7, Roland Zimmermann # 5, 6, 7, Martin Meuli # 8, 5, 10, 7

Over the past 10 years, over 150 fetal spina bifida surgeries were performed at the Zurich Center for Fetal Diagnosis and Therapy. This study looks at surrogates for success and failure of this approach.

Journal: Springer Pediatric Surgery International - published online: 12 January 2021

Date: 20/01/2021

1 Department of Pediatric Surgery, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland. ueli.moehrlen@kispi.uzh.ch.

2 The Zurich Center for Fetal Diagnosis and Therapy, Zurich, Switzerland. ueli.moehrlen@kispi.uzh.ch.

3 Children's Research Center, University Children's Hospital of Zurich, University of Zurich, Zurich, Switzerland. ueli.moehrlen@kispi.uzh.ch.

4 University of Zurich, Zurich, Switzerland. ueli.moehrlen@kispi.uzh.ch.

5 The Zurich Center for Fetal Diagnosis and Therapy, Zurich, Switzerland.

6 Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland.

7 University of Zurich, Zurich, Switzerland.

8 Department of Pediatric Surgery, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland.

9 Zurich Center for Spina Bifida, University Children's Hospital Zurich, Zurich, Switzerland.

10 Children's Research Center, University Children's Hospital of Zurich, University of Zurich, Zurich, Switzerland.

11 Division of Pediatric Neurology, University Children's Hospital Zurich, Zurich, Switzerland.

12 Division of Intensive Care and Neonatology, University Children' Hospital Zurich, Zurich, Switzerland.

13 Division of Diagnostic Imaging, MR-Center, University Children's Hospital Zurich, Zurich, Switzerland.

14 Division of Pediatric Rehabilitation, University Children's Hospital Zurich, Zurich, Switzerland.

15 Department of Neonatology, University Hospital Zurich, Zurich, Switzerland.

# Contributed equally.

Urological Outcome after Fetal Spina Bifida Repair: Data from the Zurich Cohort

Luca Mazzone 1, 2, 3, Alice Catherine Hölscher 4, 5, Ueli Moehrlen 6, 5, 7, Rita Gobet 4, 5, Martin Meuli 6, 5, 7, Maya Horst 4, 5

Neurogenic lower urinary tract dysfunction (NLUTD) represents a severe burden for patients with open spina bifida (OSB). The effect of fetal OSB repair on the urological outcome remains unclear, as controversial data exist. The aim of this study was to further increment existing outcome data and to demonstrate that our earlier published positive preliminary results are not erratic.

Journal: Karger Fetal Diagnosis and Therapie - published online: September 7, 2020

Date: 01/12/2020

1 The Zurich Center for Fetal Diagnosis and Therapy, Zurich, Switzerland, luca.mazzone@kispi.uzh.ch.

2 Division of Pediatric Urology, University Children's Hospital Zurich, Zurich, Switzerland, luca.mazzone@kispi.uzh.ch.

3 Children's Research Center, University Children's Hospital of Zurich, University of Zurich, Zurich, Switzerland, luca.mazzone@kispi.uzh.ch.

4 Division of Pediatric Urology, University Children's Hospital Zurich, Zurich, Switzerland.

5 Children's Research Center, University Children's Hospital of Zurich, University of Zurich, Zurich, Switzerland.

6 The Zurich Center for Fetal Diagnosis and Therapy, Zurich, Switzerland.

7 Department of Pediatric Surgery, University Children's Hospital Zurich, Zurich, Switzerland.

Determination of Anatomical Levels in Spina Bifida Fetuses with Ultrasound and MRI

Ladina Vonzun 1 2, Maike Katja Kahr 1, David Wille 3 4, Raimund Kottke 5 4, Ueli Moehrlen 6 2 4, Martin Meuli 6 2 4, Nicole Ochsenbein-Kölble 1 2, Franziska Kraehenmann 1 2, Roland Zimmermann 1 2, Luca Mazzone 6 2 4

The goal of this study was to assess the accuracy of prenatal anatomical level determination by ultrasound (US) and magnetic resonance imaging (MRI) by analyzing the congruence with the "true" anatomical level identified by postnatal MRI.

Journal: Thieme Ultraschall in Med - published online: 2. Oktober 2020

Date: 02/10/2020

1Department of Obstetrics, University Hospital of Zurich, Frauenklinikstrasse 10, 8006 Zurich, Switzerland.

2The Zurich Center for Fetal Diagnosis and Therapy (www.swissfetus.ch), University of Zurich, Zurich, Switzerland.

3Department of Pediatric Neurology, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland.

4Spina Bifida Center, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland.

5Department of Diagnostic Imaging, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland.

6Department of Pediatric Surgery, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland.

Open Intrauterine Fetal Myelomeningocele Repair: Changes in the Surgical Procedure and Perinatal Complications during the First 8 Years of Experience at a Single Center

Maike K Kahr 1 2, Franziska M Winder 3 4, Ladina Vonzun 3 4, Luca Mazzone 5 4, Ueli Moehrlen 5 4, Martin Meuli 5 4, Margaret Hüsler 3 4, Franziska Krähenmann 3 4, Roland Zimmermann 3 4, Nicole Ochsenbein-Kölble 3 4

Open fetal myelomeningocele (fMMC) repair is nowadays a therapeutic option in selected cases. We aimed to evaluate changes in maternal and fetal outcome after fMMC repair during the first 8 years of experience at a tertiary referral fetal medicine center in Switzerland. -Materials and Methods: Between 2010 and 2018, fMMC repair and delivery of the neonate via planned cesarean section was performed in 67 cases. Cases were retrospectively stratified into 2 groups: a "training phase" (TP) with supervision from an external surgeon during 11 operations (2010-2014, 15 cases) followed by an "experienced phase" (EP, 2014-2018, 52 cases); each phase lasted about 4 years. Both phases were compared with regard to various maternal and fetal outcome parameters.

Journal: Karger Fetal Diagnosis and Therapie - published online: December 4, 2019

Date: 01/06/2020

1Division of Obstetrics, University Hospital of Zurich, Zurich, Switzerland, maikekatja.kahr@usz.ch.

2The Zurich Center for Fetal Diagnosis and Therapy, University of Zurich, Zurich, Switzerland, maikekatja.kahr@usz.ch.

3Division of Obstetrics, University Hospital of Zurich, Zurich, Switzerland.

4The Zurich Center for Fetal Diagnosis and Therapy, University of Zurich, Zurich, Switzerland.

5Department of Pediatric Surgery, University Children's Hospital Zurich, Zurich, Switzerland.

Hindbrain Herniation and Banana and Lemon Sign After Open Fetal Myelomeningocele Repair - When Do These Signs Disappear and is Shunting Predictable?

Ladina Vonzun 1 2, Franziska Maria Winder 2, Martin Meuli 1 3, Ueli Moehrlen 1 3, Luca Mazzone 1 3, Franziska Kraehenmann 1 2, Margaret Huesler 1 2, Roland Zimmermann 1 2, Nicole Ochsenbein-Kölble 1 2

The aim was to describe the sonographic follow-up of hindbrain herniation (HH), the banana and lemon sign after fetal myelomeningocele (fMMC) repair, and the time of disappearance of these signs after the intervention, and to investigate any predictive value for the necessity of shunting during the infant's first year of life. Additionally, the sonographic evolution of the transcerebellar diameter (TCD) before and after fetal intervention was assessed.

Journal: Thieme Ultraschall in Med.

Date: 24/04/2020

1University Hospital Zurich, The Zurich Center for Fetal Diagnosis and Therapy, Zurich, Switzerland.

2Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland.

3University Children's Hospital Zurich, Spina-Bifida-Center, Zurich, Switzerland.