Publikationen

    Long-term Outcomes of Children After Fetal Surgery for Spina Bifida-Toward Sustainability

    Martin Meuli 1, 2, 3, Ueli Moehrlen 1, 2, 3

    No abstract available

    PMID: 33555285 DOI: 10.1001/jamapediatrics.2020.5687

    Journal: JAMA Pediatrics 2021;175(4):e205687 - published online: February 8, 2021

    Date: 01/04/2021

    1 Department of Pediatric Surgery, University Children's Hospital Zurich, Zurich, Switzerland.

    2 The Zurich Center for Fetal Diagnosis and Therapy, University of Zurich, Zurich, Switzerland.

    3 Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.

    Fetal surgery for spina bifida in Zurich: results from 150 cases

    Ueli Moehrlen 1, 2, 3, 4, Nicole Ochsenbein 5, 6, 7, Ladina Vonzun 5, 6, Luca Mazzone 8, 5, 9, 10, Maya Horst 8, 9, 10, Sonja Schauer 8, 9, 10, David Alexander Wille 11, 9, 10, Cornelia Hagmann 12, 10, Raimund Kottke 13, 10, Patrice Grehten 13, 10, Barbara Casanova 8, 5, 10, Nele Strübing 5, 6, Theres Moehrlen 8, 5, 10, Sasha Tharakan 8, 5, 10, Beth Padden 14, 9, 10, Dirk Bassler 15, 7, Roland Zimmermann # 5, 6, 7, Martin Meuli # 8, 5, 10, 7

    Over the past 10 years, over 150 fetal spina bifida surgeries were performed at the Zurich Center for Fetal Diagnosis and Therapy. This study looks at surrogates for success and failure of this approach.

    PMID: 33432393 DOI: 10.1007/s00383-020-04824-8

    Journal: Springer Pediatric Surgery International - published online: 12 January 2021

    Date: 20/01/2021

    1 Department of Pediatric Surgery, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland. ueli.moehrlen@kispi.uzh.ch.

    2 The Zurich Center for Fetal Diagnosis and Therapy, Zurich, Switzerland. ueli.moehrlen@kispi.uzh.ch.

    3 Children's Research Center, University Children's Hospital of Zurich, University of Zurich, Zurich, Switzerland. ueli.moehrlen@kispi.uzh.ch.

    4 University of Zurich, Zurich, Switzerland. ueli.moehrlen@kispi.uzh.ch.

    5 The Zurich Center for Fetal Diagnosis and Therapy, Zurich, Switzerland.

    6 Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland.

    7 University of Zurich, Zurich, Switzerland.

    8 Department of Pediatric Surgery, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland.

    9 Zurich Center for Spina Bifida, University Children's Hospital Zurich, Zurich, Switzerland.

    10 Children's Research Center, University Children's Hospital of Zurich, University of Zurich, Zurich, Switzerland.

    11 Division of Pediatric Neurology, University Children's Hospital Zurich, Zurich, Switzerland.

    12 Division of Intensive Care and Neonatology, University Children' Hospital Zurich, Zurich, Switzerland.

    13 Division of Diagnostic Imaging, MR-Center, University Children's Hospital Zurich, Zurich, Switzerland.

    14 Division of Pediatric Rehabilitation, University Children's Hospital Zurich, Zurich, Switzerland.

    15 Department of Neonatology, University Hospital Zurich, Zurich, Switzerland.

    # Contributed equally.

    Urological Outcome after Fetal Spina Bifida Repair: Data from the Zurich Cohort

    Luca Mazzone 1, 2, 3, Alice Catherine Hölscher 4, 5, Ueli Moehrlen 6, 5, 7, Rita Gobet 4, 5, Martin Meuli 6, 5, 7, Maya Horst 4, 5

    Neurogenic lower urinary tract dysfunction (NLUTD) represents a severe burden for patients with open spina bifida (OSB). The effect of fetal OSB repair on the urological outcome remains unclear, as controversial data exist. The aim of this study was to further increment existing outcome data and to demonstrate that our earlier published positive preliminary results are not erratic.

    PMID: 32894833 PMCID: PMC7845448 DOI: 10.1159/000509392

    Journal: Karger Fetal Diagnosis and Therapie - published online: September 7, 2020

    Date: 01/12/2020

    1 The Zurich Center for Fetal Diagnosis and Therapy, Zurich, Switzerland, luca.mazzone@kispi.uzh.ch.

    2 Division of Pediatric Urology, University Children's Hospital Zurich, Zurich, Switzerland, luca.mazzone@kispi.uzh.ch.

    3 Children's Research Center, University Children's Hospital of Zurich, University of Zurich, Zurich, Switzerland, luca.mazzone@kispi.uzh.ch.

    4 Division of Pediatric Urology, University Children's Hospital Zurich, Zurich, Switzerland.

    5 Children's Research Center, University Children's Hospital of Zurich, University of Zurich, Zurich, Switzerland.

    6 The Zurich Center for Fetal Diagnosis and Therapy, Zurich, Switzerland.

    7 Department of Pediatric Surgery, University Children's Hospital Zurich, Zurich, Switzerland.

    Determination of Anatomical Levels in Spina Bifida Fetuses with Ultrasound and MRI

    Ladina Vonzun 1 2, Maike Katja Kahr 1, David Wille 3 4, Raimund Kottke 5 4, Ueli Moehrlen 6 2 4, Martin Meuli 6 2 4, Nicole Ochsenbein-Kölble 1 2, Franziska Kraehenmann 1 2, Roland Zimmermann 1 2, Luca Mazzone 6 2 4

    The goal of this study was to assess the accuracy of prenatal anatomical level determination by ultrasound (US) and magnetic resonance imaging (MRI) by analyzing the congruence with the "true" anatomical level identified by postnatal MRI.

    PMID: 33007788 DOI: 10.1055/a-1264-7785

    Journal: Thieme Ultraschall in Med - published online: 2. Oktober 2020

    Date: 02/10/2020

    1Department of Obstetrics, University Hospital of Zurich, Frauenklinikstrasse 10, 8006 Zurich, Switzerland.

    2The Zurich Center for Fetal Diagnosis and Therapy (www.swissfetus.ch), University of Zurich, Zurich, Switzerland.

    3Department of Pediatric Neurology, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland.

    4Spina Bifida Center, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland.

    5Department of Diagnostic Imaging, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland.

    6Department of Pediatric Surgery, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland.

    Open Intrauterine Fetal Myelomeningocele Repair: Changes in the Surgical Procedure and Perinatal Complications during the First 8 Years of Experience at a Single Center

    Maike K Kahr 1 2, Franziska M Winder 3 4, Ladina Vonzun 3 4, Luca Mazzone 5 4, Ueli Moehrlen 5 4, Martin Meuli 5 4, Margaret Hüsler 3 4, Franziska Krähenmann 3 4, Roland Zimmermann 3 4, Nicole Ochsenbein-Kölble 3 4

    Open fetal myelomeningocele (fMMC) repair is nowadays a therapeutic option in selected cases. We aimed to evaluate changes in maternal and fetal outcome after fMMC repair during the first 8 years of experience at a tertiary referral fetal medicine center in Switzerland. -Materials and Methods: Between 2010 and 2018, fMMC repair and delivery of the neonate via planned cesarean section was performed in 67 cases. Cases were retrospectively stratified into 2 groups: a "training phase" (TP) with supervision from an external surgeon during 11 operations (2010-2014, 15 cases) followed by an "experienced phase" (EP, 2014-2018, 52 cases); each phase lasted about 4 years. Both phases were compared with regard to various maternal and fetal outcome parameters.

    PMID: 31801139 DOI: 10.1159/000503388

    Journal: Karger Fetal Diagnosis and Therapie - published online: December 4, 2019

    Date: 01/06/2020

    1Division of Obstetrics, University Hospital of Zurich, Zurich, Switzerland, maikekatja.kahr@usz.ch.

    2The Zurich Center for Fetal Diagnosis and Therapy, University of Zurich, Zurich, Switzerland, maikekatja.kahr@usz.ch.

    3Division of Obstetrics, University Hospital of Zurich, Zurich, Switzerland.

    4The Zurich Center for Fetal Diagnosis and Therapy, University of Zurich, Zurich, Switzerland.

    5Department of Pediatric Surgery, University Children's Hospital Zurich, Zurich, Switzerland.